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323 A Decade of HIV Vaccine Development in Thailand
J. G. McNeil for the US Army-Royal Thai Army HIV Res. Collaboration and the Thailand HIV/AIDS Vaccine Evaluation Group
Walter Reed Army Inst. of Res., Rockville, Maryland, USA
Background: For over a decade, the US Army HIV Research Program and government and academic institutions in Thailand have collaborated on epidemiological, immunological, clinical, and socio-behavioral studies providing the required framework for HIV vaccine development in and for Thailand. The singular goal of all activities is an efficacious vaccine for the prevention of HIV/AIDS.
Methods: Descriptive studies of the epidemiology of HIV, including measures of prevalence and incidence. Cohort development studies including epidemiological assessment, socio-behavioral assessments, education, and other prevention interventions. Clinical, virological, and immunological assessment of HIV infection. Human studies of HIV candidate vaccines. Concomitant capacity building.
Results: Epidemiological data supporting the design and implementation of a phase III trial. Cohort study data necessary to design and implement a phase III trial. Human clinical data necessary to advance an HIV vaccination strategy to phase III trial. Development of the necessary capacity, both physical and human, to design and implement a phase III trial.
Conclusions: Ten years of focused collaboration have resulted in the capacity and opportunity to test a leading first-generation HIV vaccine candidate strategy in a phase III trial in Thailand. This efficacy trial is in advanced strategies of planning and is anticipated to commence mid-2002. Specific details will be presented.
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