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13. Poster Session
T-Cell Epitope Mapping

Abstracts

#Title
49 Clustering of Dominant CTL Epitopes in a Cohort of HIV+ Minority Adolescents
A. Bansal*, S. Sabbaj, B. Edwards, D. Ritter, J. Tang, B. Korber, R. Kaslow, C. Wilson, P. Goepfert, and M. Mulligan
Univ. of Alabama at Birmingham, USA

50 Nef-Specific T-Cell Responses in HIV-Infected African-American (A-A) and Hispanic (H) Adolescents
A. Bansal, D. Ritter, S. Sabbaj, C. Perkins, B. Edwards, B. Korber, R. Kaslow, C. Wilson, P. Goepfert, and M. Mulligan*
Univ. of Alabama at Birmingham, USA

51 Influence of the Antigen and the Assay on the Characterisation of CTL Responses to HIV-1
E. Iglesias, A. Samri*, G. Kamkamidze, Y. Sun, G. Carcelain, C. Quillent-Gregoire, P. Debre, and B. Autran
Hosp. Pitié-Salpêtrière, Paris, France

52 HIV+ve Lymphocytes Infected in Vitro with Recombinant Fowlpox Virus (rFPV) Vaccines Stimulate Autologous HIV-Specific Cytotoxic T Cells (CTLs)
E. Benson*1, M. Bharadwaj2, J. Clarkson3, C. Webber1, and S. Adams1
1Westmead Hosp., NSW, Australia; 2Queensland Inst. of Med. Res., QLD, Australia; and 3Westmead Childrens’ Hosp., NSW, Australia

53 Predominant HIV-1C-Specific CTL Responses
V. Novitsky*1, N. Rybak1, M. F. McLane1, P. Gilbert1, P. Chigwedere1, I. Klein1, S. Gaolekwe2, S. Y. Chang1, T. Peter3, I. Thior3, T. Ndung’u1, F. Vannberg4, B. T. Foley5, R. Marlink1, T. H. Lee1, and M. Essex1
1HSPH, Boston, MA, USA; 2NHL, Gaborone, Botswana; 3BHP, Gaborone, Botswana; 4HMS, Boston, MA, USA; and 5LANL, Los Alamos, NM, USA

55 New Cytotoxic T-Cell Epitopes and MHC Restrictions in HIV-Infected African-American Adolescents
S. Sabbaj*, A. Bansal, D. Ritter, C. Perkins, B. Edwards, J. Tang, B. Korber, C. Wilson, R. Kaslow, P. Goepfert, and M. Mulligan
Univ. of Alabama at Birmingham, USA

56 Important Contribution of p15 Gag-Specific Responses to the Total Gag-Specific CTL Responses
X. G. Yu*1,2, H. Shang2, M. M. Addo1, R. Eldridge1, M. N. Philips1, D. Strick1, C. Brander1, P. J. R. Goulder1,3, E. S. Rosenberg1, B. D. Walker1, and M. Altfeld1
1Massachusetts Gen. Hosp./Harvard Med. Sch., Boston, USA; 2First Affiliated Hosp. China Med. Univ., Shenyang, China; and 3John Radcliffe Hosp., Oxford, UK

57 Rapid and Comprehensive Characterization of HIV-1-Specific CTL Responses Using a Peptide-Matrix-System Spanning All Expressed HIV-1 Proteins
M. M. Addo1, X. G. Yu*1, D. Cohen2, R. Eldridge1, M. Philips1, C. Brander1, S. Boswell2, P. Goulder1, E. Rosenberg1, M. Altfeld1, and B. D. Walker1
1AIDS Res. Ctr., MGH, Boston, MA, USA and 2Fenway CHC, Boston, MA, USA

58 Clustered T-Helper Determinants in the HIV Envelope Protein
T. Lockey*, S. Surman, K. S. Slobod, B. Jones, J. Riberdy, B. Brown, A. Zirkel, S. White, P. Doherty, and J. L. Hurwitz
St. Jude Children’s Res. Hosp., Memphis, TN, USA

59 Detailed Analysis of CD4+ T-Helper Responses to Env and Gag Proteins of Simian Immunodeficiency Virus Reveals a Relative Lack of Broadly Reactive CD4+ T-Helper Epitopes in the SU Domain of Env
S. Sarkar*, V. Kalia, M. Murphey-Corb, and R. C. Montelaro
Univ. of Pittsburgh, PA, USA

60 Allocation of Helper T-Cell Epitope Immunodominance According to Three-Dimensional Structure in the Human Immunodeficiency Virus Type I Envelope Glycoprotein gp120
S. J. Landry*, G. Dai, and N. K. Steede
Tulane Univ. Hlth. Sci. Ctr., New Orleans, LA, US

61 Identification of Novel HIV-2 Epitopes and Cross-Reactive HIV-1/HIV-2 Epitopes Using a Bioinformatics Approach
N. Chinai1, A. Jaye2, A. Bosma1, A. Alabi2, S. Sabally2, C. Saint-Aubin1, H. Whittle2, and A. S. De Groot*1
1Brown Univ., Providence, RI, USA and 2Med. Res. Labs, Fajara, The Gambia