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5. Slide Session
Virology
Moderators:Francine McCutchan, Henry M. Jackson Fndn., Rockville, MD, USA and Larry Arthur, NCI, Frederick, MD, USA

Abstracts

#Title
13 Determinants in the HIV-1 Cytoplasmic Tail That Induce Exposure of CD4-Induced Epitopes in gp120
S. Wyss*1, T. Edwards1, F. Baribaud1, J. Romano1, P. J. Vance1, S. Zolla-Pazner2, R. W. Doms1, and J. A. Hoxie1
1Univ. of Pennsylvania, Philadelphia, USA and 2VA Med. Ctr., New York, NY, USA

14 Modifications in the Cytoplasmic Domain of HIV-1 Env Allow Exposure of the Conserved Coreceptor-Binding Site and Enhance Neutralization Sensitivity
F. Baribaud*1, T. G. Edwards1, S. Wyss1, J. D. Reeves1, S. Zolla-Pazner2, J. A. Hoxie1, and R. W. Doms1
1Univ. of Pennsylvania, Philadelphia, USA and 2VA Med. Ctr., New York, NY, USA

15 Fusion Proteins of gp120 and gp41 Joined by Flexible Linkers as Potent Inhibitors of HIV-1 Entry and Candidate Vaccines
Y.-H. Chow*1, O. Wei1,2, C. Broder2, and D. Dimitrov1
1NCI-FCRDC, NIH, Frederick, MD, USA and 2Uniformed Services Univ. of the Hlth. Sci., Bethesda, MD, USA

16 Purification, Structural Characterization, and Immunogenicity of HIV-1 Envelope Oligomer from the Primary R5 Subtype B Strains
I. Srivastava*, A. Fong, E. Kan, H. Legg, S. Hilt, Y. Lian, K. Matsuoka, E. Calderon, M. Wininger, J. Ulmer, and S. Barnett
Chiron Corp., Emeryville, CA, USA

17 Immunotype and CD4 Independence of HIV-1 Envelope with Broad Primary Virus Neutralizing Cross-Reactivity Is Determined by Unusual V3 Sequence
P. F. Zhang*1, P. Bouma1, S. Zolla-Pazner3, J. Margolik2, J. Robinson4, and G. Quinnan1
1Uniformed Services Univ. of the Hlth. Sci., Bethesda, MD, USA; 2Johns Hopkins Univ., Baltimore, MD, USA; 3New York Univ., New York, USA; and 4Tulane Univ., New Orleans, LA, USA

18 The Initial Attachment and Penetration of HIV-1 into the Vaginal Mucosa Occurs Independently of the Viral gp120 Glycoprotein
H. Liu1, L. Lai1, Y. Jia1, A. Tousson1, J. C. Kappes1,2, and X. Wu*1
1Univ. of Alabama at Birmingham, USA and 2Med. Res. Service, Dept. of Veterans Affairs, Birmingham, AL, USA

19 R-113281 (a Combined Tachykinin Receptor Antagonist) Potently Inhibits HIV-1 Infection of Human Blood Mononuclear Phagocytes
J.-P. Lai*, X. Wang, T. Nishi, Y. Li, L. Song, W.-Z. Ho, and S. D. Douglas
The Children's Hosp. of Philadelphia, Univ. of Pennsylvania Sch. of Med., Philadelphia, USA

20 A Nucleotide Substitution in the Lys tRNA Primer Binding Site Dramatically Increases Replication of Recombinant SIV Containing HIV-1 Reverse Transcriptase
K. Soderberg*1, R. C. Desrosiers2, and L. Alexander1
1Yale Univ., New Haven, CT, USA and 2 Harvard Univ., Southborough, MA, USA