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8. Slide Session
Novel Immune Responses
Moderators: Steven Harrison, Harvard Univ., Cambridge, MA, USA and Frank Miedema, Univ. of Amsterdam/CLB, The Netherlands

Abstracts

#Title
29 Mucosal AIDS Vaccine Reduces Disease and Viral Load in Gut Reservoir and Blood after Mucosal Infection of Macaques
I. M. Belyakov*1, Z. Hel1, B. Kelsall2, V. A. Kuznetsov3, J. D. Ahlers1, J. Nacsa1, D. I. Watkins4, T. M. Allen4, A. Sette5, J. Altman6, R. Woodward7, P. D. Markham7, J. D. Clements8, G. Franchini1, W. Strober2, and J. A. Berzofsky1
1NCI, Bethesda, MD, USA; 2NIAID, Bethesda, MD, USA; 3NICHHD, Bethesda, MD, USA; 4Wisconsin Reg. Primate Res. Ctr., Madison, USA; 5Epimmune, San Diego, CA, USA; 6Emory Univ., Atlanta, GA, USA; 7ABL Inc., Kensington, MD, USA; and 8Tulane Univ., New Orleans, LA, USA
30 Functional Impairment of EBV- and HIV-Specific CD8+ T Cells in HIV Infection: CD27 Provides a Clue
D. van Baarle*, S. Kostense, E. Hovenkamp, J. Joling, N. Dukers, M. van Oers, and F. Miedema
CLB Sanquin and Univ. of Amsterdam, The Netherlands
31 The Frequency of CD8+ T-Cell Responses against the Human Immunodeficiency Virus Type 1 Gag Proteins Correlates Inversely with Plasma Viral Load
B. Edwards, A. Bansal, S. Sabbaj, M. Mulligan, and P. Goepfert*
Univ. of Alabama at Birmingham, USA
32 Immune Recognition of Conserved Regions within Nef from HIV-1 Subtype C-Infected Individuals from Southern Africa
T. Mashishi*1, G. Hunt1, S. Loubser2, S. Nyoka1, W. Hide3, C. Williamson2, G. Ferrari5, A. Puren1, G. Ramjee4, S. A. Karim4, H. Cao6, H. Sheppard6, and C. Gray1
1Natl. Inst. for Virology, Johannesburg, South Africa; 2Univ. of Cape Town, South Africa; 3Univ. of Western Cape, South Africa; 4Med. Res. Council, Durban, South Africa; 5Duke Univ., Durham, NC, USA; and 6California Dept. of Hlth. Services, Berkeley, USA
33 Assessment and Comparison of HIV-1-Specific T-Cell Responses in Long-Term Nonprogressors (LTNPs) and Acute Seroconverters
L. Cosimi*, H. Truong, B. Wilkes, D. Strick, B. D. Walker, and E. S. Rosenberg
Partners AIDS Res. Ctr., Massachusetts Gen. Hosp., and Harvard Med. Sch., Boston, MA, USA
34 T-Cell Receptor Repertoire Analysis in Live-Sorted Antigen-Specific T Cells Based on IFN-gamma Production
S. A. Islam, G. B. Cohen*, M. Noble, C. Lau, S. He, M. A. Altfeld, E. Rosenberg, B. D. Walker, and S. A. Kalams
Partners AIDS Res. Ctr. and Infectious Disease Unit, Massachusetts Gen. Hosp., and Harvard Med. Sch., Boston, MA, USA
35 Development of a Sensitive Flow Cytometric Assay for Measuring HIV-1 Neutralizing Antibodies in Seropositive and Vaccinated Subjects
J. Darden*1, A. Sambor1, S. Presswala1, R. McLinden1, J. Kim1, D. Birx1, V. Polonis1, and the TAVEG2
1The US Military HIV Res. Prgm., Rockville, MD, USA and 2The Thai AIDS Vaccine Evaluation Grp., Thailand, USA, and France
36 Statistical Methods for Evaluating ELISPOT Assays in HIV Vaccine Trials
S. Self*, M. Hudgens, Y. Chiu, and A. J. Rossini
Fred Hutchinson Cancer Res. Ctr., Seattle, WA, USA