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9. Slide Session
Animal Models
Moderators: John Shiver, Merck Res. Labs, West Point, PA, USA and Harriet Robinson, Yerkes Reg. Primate Res. Ctr. of Emory Univ., Atlanta, GA, USA

Abstracts

#Title
37 Replication-Incompetent Recombinant Adenovirus Vector Expressing SIV gag Elicits Robust and Effective Cellular Immune Responses in Rhesus Macaques
T.-M. Fu, W. Trigona*, M.-E. Davies, Z.-Q. Zhang, D. Casimiro, S. Dubey, D. C. Freed, J. Joyce, K. Grimm, W. A. Schleif, N. L. Letvin, E. A. Emini, and J. W. Shiver
Merck Res. Labs, West Point, PA, USA

38 An Effective AIDS Vaccine Based on Live-Attenuated Vesicular Stomatitis Virus Recombinants
N. Rose1, P. Marx2,3, A. Luckay3, D. Nixon4, W. Moretto4, S. Donahoe4, D. Montefiori5, A. Roberts1, and J. Rose*1
1Yale Univ. Sch. of Med., New Haven, CT, USA; 2Aaron Diamond AIDS Res. Ctr., New York, NY, USA; 3Tulane Reg. Primate Ctr., Covington, LA, USA; 4Gladstone Inst., San Francisco, CA, USA; and 5Duke Univ. Med. Ctr., Durham, NC, USA

39 Early Antiretroviral Treatment Facilitates CD8+ Lymphocyte-Mediated Control of Pathogenic SIV Infection and Resistance to Homologous and Heterologous Rechallenge
J. D. Lifson*1, J. L. Rossio1, M. Piatak, Jr.1, B. M. Flynn2, B. Fisher2, R. C. Desrosiers3, V. M. Hirsch4, K. Reimann5, J. Schmitz5, J. Ghrayeb6, N. Bischofberger7, D. Wodarz8, and M. A. Nowak8
1AVP, SAIC Frederick, NCI at Frederick, MD, USA; 2ASB/NCI, Bethesda, MD, USA; 3HMS/NERPRC, Southborough, MA, USA;4LMM/NIAID, Bethesda, MD, USA; 5HMS/BIMC, Boston, MA, USA; 6Centocor, Malvern, PA, USA; 7Gilead Sci., Foster City, CA, USA; and 8IAS, Princeton, NJ, USA

40 Durable Long-Term Immune Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Plasmid Cytokine-Augmented DNA Vaccination
D. H. Barouch*1, S. Santra1, J. E. Schmitz1, M. J. Kuroda1, W. Wagner2, J. Kunstman3, D. C. Montefiori4, S. M. Wolinsky3, M. G. Lewis2, and N. L. Letvin1
1BIDMC, Harvard Med. Sch., Boston, MA, USA; 2Southern Res. Inst., Frederick, MD, USA; 3Northwestern Univ., Chicago, IL, USA; and 4Duke Univ., Durham, NC, USA

41 Intrarectal Challenge of Macaques Immunized with VEE Replicon Vectors
R. Johnston*1, N. Davis1, M. Collier1, M. Connell2, A. Nielsen1, L. Hensley1, D. Montefiori3, R. Swanstrom1, J. Frelinger1, C. Walker2, and P. Johnson2
1Univ. of North Carolina, Chapel Hill, NC, USA; 2Children's Res. Inst., Columbus, OH, USA; and 3Duke Univ., Durham, NC, USA

42 Improved Efficacy of DNA Vaccination Using a New Generation of Optimized HIV and SIV Plasmids
G. N. Pavlakis1, M. Rosati1, P. Eyler1, A. Valentin1, H. Trivedi1, A. Biragyn1, L. W. Kwak1, P. Markham2, R. Woodward 2, A. von Gegerfelt1, N. Miller3, and B. K. Felber1
1NCI at Frederick, MD, USA; 2Advanced BioScience Labs, Inc., Kensington, MD, USA; and 3NIAID, NIH, Bethesda, MD, USA

43 Vaccine Protection against Functional Cytotoxic T Lymphocyte Abnormalities in Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys
P. F. McKay*, J. E. Schmitz, M. J. Kuroda, D. H. Barouch, M. A. Lifton, C. E. Nickerson, D. A. Gorgone, and N. L. Letvin
Beth Israel Deaconess Med. Ctr., Harvard Med. Sch., Boston, MA, USA

44 Working toward an AIDS Vaccine
H. L. Robinson
Emory Vaccine Ctr. and Yerkes Primate Res. Ctr., Atlanta, GA, USA